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Article

Chromosome loss is the most frequent mechanism contributing to HLA haplotype loss in human tumors

24 Sept 1999

Abstract excerpt

Loss of heterozygosity (LOH) in the short arm of chromosome 6 (6p) was detected in samples obtained from colon (13.8%), larynx (17.6%) and melanoma (15.3%) tumors. The parallel study of HLA-antigen expression in tumor tissues using locus- and polymorphic-specific antibodies in combination with LOH microsatellite analysis on 6p allowed us to establish that LOH in chromosome 6 is a representative phenomenon in most...

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Identifiers

PMID: 10449614
DOI: 10.1002/(sici)1097-0215(19990924)83:1<91::aid-ijc17>3.0.co;2-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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