Article
Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast.
Molecular biology of the cell - 1 Aug 2005
Gardner Melissa K, Pearson Chad G, Sprague Brian L, Zarzar Ted R, Bloom Kerry, Salmon E D, Odde David J
Abstract excerpt
During metaphase in budding yeast mitosis, sister kinetochores are tethered to opposite poles and separated, stretching their intervening chromatin, by singly attached kinetochore microtubules (kMTs). Kinetochore movements are coupled to single microtubule plus-end polymerization/depolymerization at kinetochore attachment sites. Here, we use computer modeling to test possible mechanisms controlling chromosome...
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