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Article

Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules.

Cell - 28 Nov 2008

Gardner Melissa K, Bouck David C, Paliulis Leocadia V, Meehl Janet B, O'Toole Eileen T, Haase Julian, Soubry Adelheid, Joglekar Ajit P, Winey Mark, Salmon Edward D, Bloom Kerry, Odde David J

Abstract excerpt

During mitosis, sister chromatids congress to the spindle equator and are subsequently segregated via attachment to dynamic kinetochore microtubule (kMT) plus ends. A major question is how kMT plus-end assembly is spatially regulated to achieve chromosome congression. Here we find in budding yeast that the widely conserved kinesin-5 sliding motor proteins, Cin8p and Kip1p, mediate chromosome congression by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19041752
DOI: 10.1016/j.cell.2008.09.046
PMCID: PMC2683758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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