Article

Insights into human outer kinetochore assembly and force transmission from a structure-function analysis of the KMN network

2023-08-07

Abstract excerpt

The biorientation of chromosomes during cell division is necessary for precise dispatching of a mother cell’s chromosomes into its two daughters. Kinetochores, large layered structures built on specialized chromosome loci named centromeres, promote biorientation by binding and sensing spindle microtubules. The kinetochore outer layer consists of a 10-subunit apparatus comprising Knl1C, Mis12C, and Ndc80C subcomple...

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Literature Corpus work: 5dc3d948-2c38-5362-8f93-61086dc39fb0
DOI: 10.1101/2023.08.07.552315

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