Article
Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores.
The Journal of cell biology - 13 Jul 2009
Matos Irina, Pereira António J, Lince-Faria Mariana, Cameron Lisa A, Salmon Edward D, Maiato Helder
Abstract excerpt
The synchronous movement of chromosomes during anaphase ensures their correct inheritance in every cell division. This reflects the uniformity of spindle forces acting on chromosomes and their simultaneous entry into anaphase. Although anaphase onset is controlled by the spindle assembly checkpoint, it remains unknown how spindle forces are uniformly distributed among different chromosomes. In this paper, we show...
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