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Article

How the kinetochore couples microtubule force and centromere stretch to move chromosomes.

Nature cell biology - 1 Apr 2016

Suzuki Aussie, Badger Benjamin L, Haase Julian, Ohashi Tomoo, Erickson Harold P, Salmon Edward D, Bloom Kerry

Abstract excerpt

The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal tail and CH domains of Ndc80 bind microtubules, and an internal domain binds...

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Identifiers

PMID: 26974660
DOI: 10.1038/ncb3323
PMCID: PMC4814359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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