Article
Measuring nanometer scale gradients in spindle microtubule dynamics using model convolution microscopy.
Molecular biology of the cell - 1 Sept 2006
Pearson Chad G, Gardner Melissa K, Paliulis Leocadia V, Salmon E D, Odde David J, Bloom Kerry
Abstract excerpt
A computational model for the budding yeast mitotic spindle predicts a spatial gradient in tubulin turnover that is produced by kinetochore-attached microtubule (kMT) plus-end polymerization and depolymerization dynamics. However, kMTs in yeast are often much shorter than the resolution limit of the light microscope, making visualization of this gradient difficult. To overcome this limitation, we combined digital...
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