Article

Computational modelling and near-complete kinetochore tracking reveal how chromosome dynamics during cell division are co-ordinated in space and time

2021-12-17

Abstract excerpt

Mitotic chromosome segregation is a self-organising process that achieves high fidelity separation of 46 duplicated chromosomes into two daughter cells. Chromosomes must be captured by the microtubule-based spindle, aligned at the spindle equator where they undergo oscillatory motion (metaphase) and then pulled to opposite spindle poles (anaphase). These large and small-scale chromosome movements are driven by kin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58662f51-1ddc-5955-852e-d828d018cd00
DOI: 10.1101/2021.12.16.472953

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational modelling and near-complete kinetochore tracking reveal how chromosome dynamics during cell division are co-ordinated in space and timeDOI 10.1101/2021.12.16.472953Read

Bayesian data driven modelling of kinetochore dynamics: space-time organisation of the human metaphase plateSemantic proximity Read

Kinetochore life histories reveal the origins of chromosome mis-segregation and correction mechanismsSemantic proximity Read

Structural plasticity of the living kinetochore.Semantic proximity Read

Insights into human outer kinetochore assembly and force transmission from a structure-function analysis of the KMN networkSemantic proximity Read

Ensemble-level organization of human kinetochores and evidence for distinct tension and attachment sensorsSemantic proximity Read

Torques within and outside the human spindle balance twist at anaphaseSemantic proximity Read

High-resolution imaging reveals how the spindle midzone impacts chromosome movementSemantic proximity Read

Measuring and modeling the dynamics of mitotic error correctionSemantic proximity Read

Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast.Semantic proximity Read

Augmin-mediated amplification of long-lived spindle microtubules directs plus-ends to kinetochoresSemantic proximity Read

Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalitiesSemantic proximity Read

A scaling law of periodic radial geometry organises eukaryotic chromosomesSemantic proximity Read