Article
Captivating capture: how microtubules attach to kinetochores.
Current biology : CB - 27 May 2003
Biggins Sue, Walczak Claire E
Abstract excerpt
Accurate chromosome segregation is essential to ensure genomic stability because the aneuploidy that results from segregation errors leads to birth defects and contributes to the development of cancer. Chromosome segregation is directed by the kinetochore, the chromosomal site of attachment to dynamic polymers called microtubules (MTs). Although the fidelity of chromosome segregation depends on precise...
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