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Article

Structural plasticity of the living kinetochore.

The Journal of cell biology - 6 Nov 2017

Dhatchinamoorthy Karthik, Shivaraju Manjunatha, Lange Jeffrey J, Rubinstein Boris, Unruh Jay R, Slaughter Brian D, Gerton Jennifer L

Abstract excerpt

The kinetochore is a large, evolutionarily conserved protein structure that connects chromosomes with microtubules. During chromosome segregation, outer kinetochore components track depolymerizing ends of microtubules to facilitate the separation of chromosomes into two cells. In budding yeast, each chromosome has a point centromere upon which a single kinetochore is built, which attaches to a single microtubule....

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Identifiers

PMID: 28939613
DOI: 10.1083/jcb.201703152
PMCID: PMC5674893

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