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Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs.

BMC genomics - 5 Apr 2005

Meaburn Emma, Butcher Lee M, Liu Lin, Fernandes Cathy, Hansen Valerie, Al-Chalabi Ammar, Plomin Robert, Craig Ian, Schalkwyk Leonard C

Abstract excerpt

BACKGROUND: Quantitative trait locus (QTL) theory predicts that genetic influence on complex traits involves multiple genes of small effect size. To detect QTL associations of small effect size, large samples and systematic screens of thousands of DNA markers are required. An efficient solution is to genotype case and control DNA pools using SNP microarrays. We demonstrate that this is practical using DNA pools...

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Identifiers

PMID: 15811185
DOI: 10.1186/1471-2164-6-52
PMCID: PMC1079828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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