Article
Identification of disease causing loci using an array-based genotyping approach on pooled DNA.
BMC genomics - 30 Sept 2005
Craig David W, Huentelman Matthew J, Hu-Lince Diane, Zismann Victoria L, Kruer Michael C, Lee Anne M, Puffenberger Erik G, Pearson John M, Stephan Dietrich A
Abstract excerpt
BACKGROUND: Pooling genomic DNA samples within clinical classes of disease followed by genotyping on whole-genome SNP microarrays, allows for rapid and inexpensive genome-wide association studies. Key to the success of these studies is the accuracy of the allelic frequency calculations, the ability to identify false-positives arising from assay variability and the ability to better resolve association signals...
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