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Article

DNA Pooling: a tool for large-scale association studies.

Nature reviews. Genetics - 1 Nov 2002

Sham Pak, Bader Joel S, Craig Ian, O'Donovan Michael, Owen Michael

Abstract excerpt

DNA pooling is a practical way to reduce the cost of large-scale association studies to identify susceptibility loci for common diseases. Pooling allows allele frequencies in groups of individuals to be measured using far fewer PCR reactions and genotyping assays than are used when genotyping individuals. Here, we discuss recent developments in quantitative genotyping assays and in the design and analysis of...

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Mutation
DNA
Gene Frequency
Genetic Techniques
Haplotypes
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 12415316
DOI: 10.1038/nrg930

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