Article
Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits.
Behavior genetics - 1 Sept 2004
Butcher Lee M, Meaburn Emma, Liu Lin, Fernandes Cathy, Hill Linzy, Al-Chalabi Ammar, Plomin Robert, Schalkwyk Leo, Craig Ian W
Abstract excerpt
Large samples and systematic screens of thousands of DNA markers are needed to detect quantitative trait loci (QTLs) of small effect size. One approach to conduct systematic genome scans for association is to use microarrays which, although expensive and non-reusable, simultaneously genotype thousands of single-nucleotide polymorphisms (SNPs). This brief report provides proof of principle that groups of pooled...
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