Article
Large-scale determination of SNP allele frequencies in DNA pools using MALDI-TOF mass spectrometry.
Human mutation - 1 Jul 2002
Werner Monika, Sych Michael, Herbon Nicole, Illig Thomas, König Inke R, Wjst Matthias
Abstract excerpt
One of the major challenges in the near future is the identification of genes that contribute to complex disorders. Large scale association studies that utilize a dense map of single nucleotide polymorphisms (SNPs) have been considered as a valuable tool for this purpose. However, genome-wide screens are limited by costs of genotyping thousands of SNPs in a large number of individuals. Here we present a pooling...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.