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Article

The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.

EMBO reports - 1 Mar 2005

Cayuela María Luisa, Flores Juana M, Blasco María A

Abstract excerpt

A role for the telomerase reverse transcriptase subunit (Tert) in tumorigenesis independent of telomere length is emerging. K5-Tert mice, which overexpress Tert in the skin, show increased tumorigenesis and faster wound healing than wild-type controls. Here, we demonstrate that the telomerase RNA component Terc is necessary to mediate these effects of Tert overexpression. In contrast to K5-Tert mice, K5-Tert mice...

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Identifiers

PMID: 15731767
DOI: 10.1038/sj.embor.7400359
PMCID: PMC1299269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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