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Article

CRISPR/Cas9-Mediated TERT Disruption in Cancer Cells

19 Jan 2020

Abstract excerpt

Mammalian telomere lengths are primarily regulated by telomerase, a ribonucleoprotein consisting of a reverse transcriptase (TERT) and an RNA subunit (TERC). TERC is constitutively expressed in all cells, whereas TERT expression is temporally and spatially regulated, such that in most adult somatic cells, TERT is inactivated and telomerase activity is undetectable. Most tumor cells activate TERT as a mechanism...

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Share to CRISPR and Genetic Engineering
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Identifiers

PMID: 31963842
DOI: 10.3390/ijms21020653

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