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Telomerase reverse transcriptase gene knock‐in unleashes enhanced longevity and accelerated damage repair in mice

11 Dec 2024

Abstract excerpt

While previous research has demonstrated the therapeutic efficacy of telomerase reverse transcriptase (TERT) overexpression using adeno-associated virus and cytomegalovirus vectors to combat aging, the broader implications of TERT germline gene editing on the mammalian genome, proteomic composition, phenotypes, lifespan extension, and damage repair remain largely unexplored. In this study, we elucidate the...

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PMID: 39660787
DOI: 10.1111/acel.14445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Telomerase reverse transcriptase gene knock‐in unleashes enhanced longevity and accelerated damage repair in micePMID 39660787Read ↗

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.Semantic proximity Read ↗

Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescenceSemantic proximity Read ↗

The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.Semantic proximity Read ↗

TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.Semantic proximity Read ↗

TERT drives liver tumorigenesis beyond telomere elongationSemantic proximity Read ↗

Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.Semantic proximity Read ↗

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.Semantic proximity Read ↗

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeresSemantic proximity Read ↗

TERT drives liver tumorigenesis beyond telomere elongation.Semantic proximity Read ↗

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytesSemantic proximity Read ↗

Gene therapy with the TRF 1 telomere gene rescues decreased TRF 1 levels with aging and prolongs mouse health spanSemantic proximity Read ↗

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Semantic proximity Read ↗

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