Article

TERT drives liver tumorigenesis beyond telomere elongation

2026-02-05

Abstract excerpt

We generated two mouse models, p21 ⁺/Tert and p21 ⁺/TertCi , expressing either telomerase reverse transcriptase (TERT) or a catalytically inactive variant under the control of the p21 promoter. By 18–20 months of age, approximately 25% of mice from both genotypes developed liver tumors with histopathological features resembling human hepatocellular carcinoma (HCC). Whole-exome sequencing identified activating Ct...

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Literature Corpus work: 9fdf5691-2cde-5954-a505-4c20084ff5f1
DOI: 10.64898/2026.02.02.703327

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