Article
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.
PLoS genetics - 1 Jan 2008
Choi Jinkuk, Southworth Lucinda K, Sarin Kavita Y, Venteicher Andrew S, Ma Wenxiu, Chang Woody, Cheung Peggie, Jun Sohee, Artandi Maja K, Shah Naman, Kim Stuart K, Artandi Steven E
Abstract excerpt
Telomerase serves a critical role in stem cell function and tissue homeostasis. This role depends on its ability to synthesize telomere repeats in a manner dependent on the reverse transcriptase (RT) function of its protein component telomerase RT (TERT), as well as on a novel pathway whose mechanism is poorly understood. Here, we use a TERT mutant lacking RT function (TERT(ci)) to study the mechanism of TERT...
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