Article

Telomerase reactivation induces progression of mouse Braf <sup>V600E</sup> -driven thyroid cancers without telomere lengthening

2023-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the promoter of the telomerase reverse transcriptase ( TERT ) gene are the paradigm of a cross-cancer alteration in a non-coding region. TERT promoter mutations (TPMs) are biomarkers of poor prognosis in several tumors, including thyroid cancers. TPMs enhance TERT transcription, which is otherwise silenced in adult tissues, thus reactivating a bona fide oncoprotein. To study TE...

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Literature Corpus work: 4777ff1a-06d7-5927-997c-8611a23b4a7d
DOI: 10.1101/2023.01.24.525280

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