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Article

Telomere dysfunction in Tert knockout mice delays BrafV600E -induced melanoma development.

International journal of cancer - 1 Feb 2024

Zhang Jinglong, Zhang Fan, Porter Kenneth I, Dakup Panshak P, Wang Shuwen, Robertson Gavin P, Gaddameedhi Shobhan, Zhu Jiyue

Abstract excerpt

Telomerase activation is a crucial step in melanomagenesis, often occurring because of ultraviolet radiation (UVR)-induced mutations at the telomerase gene (TERT) promoter and rendering TERT transcription in response to the activated Raf-MAP kinase pathway by BRAFV600E mutation. Due to the excessively long telomeres in mice, this process does not occur during melanomagenesis in mouse models. To investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37727982
DOI: 10.1002/ijc.34713
PMCID: PMC10840707

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Telomere dysfunction in Tert knockout mice delays BrafV600E -induced melanoma development.PMID 37727982Read ↗

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Oncogenic Braf Induces Melanocyte Senescence and Melanoma in MiceSemantic proximity Read ↗

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TERT Expression Induces Resistance to BRAF and MEK Inhibitors in BRAF-Mutated Melanoma In VitroSemantic proximity Read ↗

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