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Article

Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes.

Cancer cell - 1 Oct 2004

Argilla David, Chin Koei, Singh Mallika, Hodgson J Graeme, Bosenberg Marcus, de Solórzano Carlos Ortiz, Lockett Stephen, DePinho Ronald A, Gray Joe, Hanahan Douglas

Abstract excerpt

The telomere-stabilizing enzyme telomerase is induced in tumors and functionally associated with unlimited replicative potential. To further explore its necessity, transgenic mice expressing SV40 or HPV16 oncogenes, which elicit carcinomas in pancreas and skin, respectively, were rendered telomerase-deficient. Absence of telomerase had minimal impact on tumorigenesis, even in terc(-/-) generations (G5-7)...

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Identifiers

PMID: 15488760
DOI: 10.1016/j.ccr.2004.08.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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