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Article

TERT—Regulation and Roles in Cancer Formation

18 Nov 2020

Abstract excerpt

Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms. Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, TERT promoter germline and somatic mutations, TERT epigenetic changes, and alternative lengthening of telomere. All...

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PMID: 33329574
DOI: 10.3389/fimmu.2020.589929

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