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Article

Telomerase Upregulation Induces Progression of Mouse BrafV600E-Driven Thyroid Cancers and Triggers Nontelomeric Effects.

Molecular cancer research : MCR - 1 Nov 2023

Landa Iñigo, Thornton Caitlin E M, Xu Bin, Haase Jacob, Krishnamoorthy Gnana P, Hao Jingzhu, Knauf Jeffrey A, Herbert Zachary T, Martínez Paula, Blasco María A, Ghossein Ronald, Fagin James A

Abstract excerpt

Mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the paradigm of a cross-cancer alteration in a noncoding region. TERT promoter mutations (TPM) are biomarkers of poor prognosis in cancer, including thyroid tumors. TPMs enhance TERT transcription, which is otherwise silenced in adult tissues, thus reactivating a bona fide oncoprotein. To study TERT deregulation and its downstream...

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Identifiers

PMID: 37478162
DOI: 10.1158/1541-7786.MCR-23-0144
PMCID: PMC11193891

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Telomerase Upregulation Induces Progression of Mouse BrafV600E-Driven Thyroid Cancers and Triggers Nontelomeric Effects.PMID 37478162Read ↗

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