Article
TERT drives liver tumorigenesis beyond telomere elongation.
Life science alliance - 1 Sept 2026
Braud Laura, Vernerey Julien, Guille Arnaud, Cordier Pierre, Ginet Clémence, Egger Tom, Bernabe Manuel, Churikov Dmitri, Da Costa Quentin, Meghraoui Aïda, Desdouets Chantal, Gu Li, Bertucci François, Lachaud Christophe, Géli Vincent
Abstract excerpt
We generated two mouse models, p21+/Tert and p21+/TertCi, expressing either telomerase reverse transcriptase (Tert) or a catalytically inactive variant under the control of the p21 promoter. By 18-20 mo of age, ∼15% of mice from both genotypes developed liver tumors with histopathological features resembling human hepatocellular carcinoma (HCC). Whole-exome sequencing identified activating Ctnnb1 mutations and...
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