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Article

Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) gene.

Proceedings of the National Academy of Sciences of the United States of America - 25 Feb 2014

Shimizu Akinori, Mito Takayuki, Hayashi Chisato, Ogasawara Emi, Koba Ryusuke, Negishi Issei, Takenaga Keizo, Nakada Kazuto, Hayashi Jun-Ichi

Abstract excerpt

We generated transmitochondrial mice (mito-mice) that carry a mutation in the tRNA(Lys) gene encoded by mtDNA for use in studies of its pathogenesis and transmission profiles. Because patients with mitochondrial diseases frequently carry mutations in the mitochondrial tRNA(Lys) and tRNA(Leu(UUR)) genes, we focused our efforts on identifying somatic mutations of these genes in mouse lung carcinoma P29 cells. Of...

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Identifiers

PMID: 24510903
DOI: 10.1073/pnas.1318109111
PMCID: PMC3939884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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