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Article

Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression.

Cancer research - 15 Nov 2017

Vivian Carolyn J, Brinker Amanda E, Graw Stefan, Koestler Devin C, Legendre Christophe, Gooden Gerald C, Salhia Bodour, Welch Danny R

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mouse strain(s)-designated Mitochondrial Nuclear Exchange (MNX)-we showed that mtDNA could alter mammary tumor metastasis. Because retrograde and anterograde communication exists...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28663334
DOI: 10.1158/0008-5472.CAN-17-1473
PMCID: PMC5690839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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