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Article

Expression of Rattus norvegicus mtDNA in Mus musculus cells results in multiple respiratory chain defects.

The Journal of biological chemistry - 6 Oct 2000

McKenzie M, Trounce I

Abstract excerpt

The production of in vitro and in vivo models of mitochondrial DNA (mtDNA) defects is currently limited by a lack of characterized mouse cell mtDNA mutants that may be expected to model human mitochondrial diseases. Here we describe the creation of transmitochondrial mouse (Mus musculus) cells repopulated with mtDNA from different murid species (xenomitochondrial cybrids). The closely related Mus spretus mtDNA is...

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PMID: 10908563
DOI: 10.1074/jbc.M004070200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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