Article
Diminished tumorigenic phenotype after depletion of mitochondrial DNA.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1997
Cavalli L R, Varella-Garcia M, Liang B C
Abstract excerpt
Modulation of tumorigenicity has been considered to be a reflection of the (nuclear) genetic and cellular aberrations present in tumor cells. Recent studies have suggested that cytoplasmic elements can also contribute to the malignant phenotype of cancer, and that mitochondria may be important in...
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