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Article

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition.

Nature immunology - 1 Feb 2005

Borg Natalie A, Ely Lauren K, Beddoe Travis, Macdonald Whitney A, Reid Hugh H, Clements Craig S, Purcell Anthony W, Kjer-Nielsen Lars, Miles John J, Burrows Scott R, McCluskey James, Rossjohn Jamie

Abstract excerpt

The energetic bases of T cell recognition are unclear. Here, we studied the 'energetic landscape' of peptide-major histocompatibility complex (pMHC) recognition by an immunodominant alphabeta T cell receptor (TCR). We quantified and evaluated the effect of natural and systematic substitutions in the complementarity-determining region (CDR) loops on ligand binding in the context of the structural detail of each...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15640805
DOI: 10.1038/ni1155

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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