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Article

The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding.

Scientific reports - 13 Oct 2016

Zhang Hao, Lim Hong-Sheng, Knapp Berhard, Deane Charlotte M, Aleksic Milos, Dushek Omer, van der Merwe P Anton

Abstract excerpt

The interaction between the T cell antigen receptor (TCR) and antigenic peptide in complex with major histocompatibility complex (MHC) molecules is a crucial step in T cell activation. The relative contributions of TCR:peptide and TCR:MHC contacts to the overall binding energy remain unclear. This has important implications for our understanding of T cell development and function. In this study we used site...

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Identifiers

PMID: 27734930
DOI: 10.1038/srep35326
PMCID: PMC5062128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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