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Article

Thermodynamics of T cell receptor binding to peptide–MHC: Evidence for a general mechanism of molecular scanning

28 Sept 1999

Abstract excerpt

Antigen-dependent activation of T lymphocytes requires T cell receptor (TCR)-mediated recognition of specific peptides, together with the MHC molecules to which they are bound. To achieve this recognition in a reasonable time frame, the TCR must scan and discriminate rapidly between thousands of MHC molecules differing from each other only in their bound peptides. Kinetic analysis of the interaction between a TCR...

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PMID: 10500196
DOI: 10.1073/pnas.96.20.11446

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