Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.

doi:10.1073/pnas.1004926107

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Article

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010

Burrows Scott R, Chen Zhenjun, Archbold Julia K, Tynan Fleur E, Beddoe Travis, Kjer-Nielsen Lars, Miles John J, Khanna Rajiv, Moss Denis J, Liu Yu Chih, Gras Stephanie, Kostenko Lyudmila, Brennan Rebekah M, Clements Craig S, Brooks Andrew G, Purcell Anthony W, McCluskey James, Rossjohn Jamie

Abstract excerpt

alphabeta T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound to self-major histocompatibility complex (pMHC) molecules; however, the basis for this MHC specificity remains unclear. Despite the current dogma, evaluation of the TCR-pMHC-I structural database shows that the nongermline-encoded complementarity-determining region (CDR)-3 loops often contact the MHC-I, and the...

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PMID: 20483993
DOI: 10.1073/pnas.1004926107
PMCID: PMC2890827

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