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Article

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.

The Journal of biological chemistry - 10 Jan 2014

Cole David K, Miles Kim M, Madura Florian, Holland Christopher J, Schauenburg Andrea J A, Godkin Andrew J, Bulek Anna M, Fuller Anna, Akpovwa Hephzibah J E, Pymm Phillip G, Liddy Nathaniel, Sami Malkit, Li Yi, Rizkallah Pierre J, Jakobsen Bent K, Sewell Andrew K

Abstract excerpt

αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged (CDR3). TCR ligands compose a presentation platform (major histocompatibility complex (MHC)) and a variable antigenic component consisting of a short "foreign" peptide. The sequence of events when the TCR engages its peptide-MHC (pMHC) ligand...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24196962
DOI: 10.1074/jbc.M113.522110
PMCID: PMC3887192

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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