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Article

The basis for limited specificity and MHC restriction in a T cell receptor interface.

Nature communications - 1 Jan 2013

Piepenbrink Kurt H, Blevins Sydney J, Scott Daniel R, Baker Brian M

Abstract excerpt

αβ T cell receptors (TCRs) recognize peptides presented by major histocompatibility complex (MHC) proteins using multiple complementarity-determining region (CDR) loops. TCRs display an array of poorly understood recognition properties, including specificity, crossreactivity and MHC restriction. Here we report a comprehensive thermodynamic deconstruction of the interaction between the A6 TCR and the Tax peptide...

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Source

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Identifiers

PMID: 23736024
DOI: 10.1038/ncomms2948
PMCID: PMC3708045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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