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Article

Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors.

Biochemistry - 25 Nov 2008

Jones Lindsay L, Colf Leremy A, Bankovich Alexander J, Stone Jennifer D, Gao Yi-Gui, Chan Choi Mui, Huang Raven H, Garcia K Christopher, Kranz David M

Abstract excerpt

To understand the mechanisms that govern T cell receptor (TCR)-peptide MHC (pMHC) binding and the role that different regions of the TCR play in affinity and antigen specificity, we have studied the TCR from T cell clone 2C. High-affinity mutants of the 2C TCR that bind QL9-L(d) as a strong agoni...

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Identifiers

PMID: 18973345
DOI: 10.1021/bi801349g
PMCID: PMC2680728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18973345-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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