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Article

T cell receptor binding transition states and recognition of peptide/MHC.

Biochemistry - 20 Feb 2007

Davis-Harrison Rebecca L, Insaidoo Francis K, Baker Brian M

Abstract excerpt

T cell receptor recognition of peptide/MHC has been described as proceeding through a "two-step" process in which the TCR first contacts the MHC molecule prior to formation of the binding transition state using the germline-encoded CDR1 and CDR2 loops. The receptor then contacts the peptide using the hypervariable CDR3 loops as the transition state decays to the bound state. The model subdivides TCR binding into...

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Source

Identifiers

PMID: 17249694
DOI: 10.1021/bi061702p

Genes

CDR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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