Article
T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction.
European journal of immunology - 1 Jun 2003
Hughes Maureen M, Yassai Maryam, Sedy John R, Wehrly Tara D, Huang Ching-Yu, Kanagawa Osami, Gorski Jack, Sleckman Barry P
Abstract excerpt
The third complementarity-determining region (CDR) of the TCR alpha and beta chains forms loops that engage amino acid residues of peptides complexed with MHC. This interaction is central to the specific discrimination of antigenic-peptide-MHC complexes by the TCR. The TCRbeta chain CDR3 loop is encoded by the Dbeta gene segment and flanking portions of the Vbeta and Jbeta gene segments. The joining of these gene...
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