Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3.

Journal of molecular biology - 11 Feb 2005

Chlewicki Lukasz K, Holler Phillip D, Monti Bridget C, Clutter Matthew R, Kranz David M

Abstract excerpt

The third complementarity-determining regions (CDR3s) of antibodies and T cell receptors (TCRs) have been shown to play a major role in antigen binding and specificity. Consistent with this notion, we demonstrated previously that high-affinity, peptide-specific TCRs could be generated in vitro by mutations in the CDR3alpha region of the 2C TCR. In contrast, it has been argued that CDR1 and CDR2 are involved to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complementarity Determining Regions
Share to Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptides

Share to Protein Structure, Tertiary

Share to Receptors, Antigen, T-Cell

Share to Saccharomyces cerevisiae

Share to Sensitivity and Specificity

Share to Substrate Specificity

Source

Identifiers

PMID: 15663940
DOI: 10.1016/j.jmb.2004.11.057

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3.PMID 15663940Read ↗

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.Semantic proximity Read ↗

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.Semantic proximity Read ↗

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.Semantic proximity Read ↗

Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.Semantic proximity Read ↗

Biology-based AI Predicts T-cell Receptor Antigen Binding SpecificitySemantic proximity Read ↗

Enhanced T cell receptor specificity through framework engineering.Semantic proximity Read ↗

Systematic mutagenesis of TCR complementarity-determining region 3 residues: a single conservative substitution dramatically improves response to both multiple HLA-DR alleles and peptide variants.Semantic proximity Read ↗

Functional avidity enhancement of a T-cell receptor targeting the KRASG12D cancer neoantigen.Semantic proximity Read ↗

The role of germline-encoded T cell receptor complementarity determining regions in T cell selection and functionSemantic proximity Read ↗

Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.Semantic proximity Read ↗

Changing the peptide specificity of a human T-cell receptor by directed evolution.Semantic proximity Read ↗

Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.