Article

CDR3 binding chemistry controls TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHC

2019-10-07

Abstract excerpt

The mechanism which adapts the T-cell antigen receptor (TCR) within a given major histocompatibility complex ( MHC/HLA ) genotype is essential for protection against pathogens. Historically attributed to relative affinity, genetically vast TCRs are surprisingly focused towards a micromolar affinity for their respective peptide (p) plus MHC (pMHC) ligands. Thus, the somatic diversity of the TCR with respect to MHC...

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Identifiers and source

Literature Corpus work: 47574984-b9f4-57d1-8638-d9e5114a0292
DOI: 10.1101/796052

Open publication

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