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Article

A new twist in TCR diversity revealed by a forbidden alphabeta TCR.

Journal of molecular biology - 1 Feb 2008

McBeth Christine, Seamons Audrey, Pizarro Juan C, Fleishman Sarel J, Baker David, Kortemme Tanja, Goverman Joan M, Strong Roland K

Abstract excerpt

We report crystal structures of a negatively selected T cell receptor (TCR) that recognizes two I-A(u)-restricted myelin basic protein peptides and one of its peptide/major histocompatibility complex (pMHC) ligands. Unusual complementarity-determining region (CDR) structural features revealed by our analyses identify a previously unrecognized mechanism by which the highly variable CDR3 regions define ligand...

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Source

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Identifiers

PMID: 18155234
DOI: 10.1016/j.jmb.2007.11.020
PMCID: PMC2330282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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