Article

Somatic genetics of CDR3 control TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHC

2021-03-15

Abstract excerpt

The mechanism which adapts the T-cell antigen receptor (TCR) within a given major histocompatibility complex ( MHC/HLA ) genotype is essential for protection against pathogens. Historically attributed to relative affinity, genetically vast TCRs are surprisingly focused towards a micromolar affinity for their respective peptide (p) plus MHC (pMHC) ligands. Thus, the somatic diversity of the TCR with respect to MHC-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 61a6a032-0c1b-5af8-b93c-35959bbdfcd9
DOI: 10.21203/rs.3.rs-253324/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic genetics of CDR3 control TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHCDOI 10.21203/rs.3.rs-253324/v1Read

CDR3 binding chemistry controls TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHCSemantic proximity Read

Conserved Biophysical Compatibility Among the Highly Variable Germline-Encoded Regions Shapes TCR-MHC InteractionsSemantic proximity Read

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometrySemantic proximity Read

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.Semantic proximity Read

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.Semantic proximity Read

Apposed networks of interacting TCRs and BCRs exhibiting mosaicked CDR3 sequences made of fixed junctional motifsSemantic proximity Read

TCR3d: The T cell receptor structural repertoire databaseSemantic proximity Read

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.Semantic proximity Read

Sequence-structure-function relationships in class I MHC: a local frustration perspectiveSemantic proximity Read

The basis for limited specificity and MHC restriction in a T cell receptor interface.Semantic proximity Read

Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms.Semantic proximity Read

A new twist in TCR diversity revealed by a forbidden alphabeta TCR.Semantic proximity Read