Mutational load and the transition between diploidy and haploidy in experimental populations of the yeast Saccharomyces cerevisiae.

Abstract excerpt

Mutations were accumulated over hundreds of generations in a mutator strain of yeast in a constant laboratory environment. This ensured that mutations were frequent and that the quality of environment remained unchanged. Mutations were accumulated in asexual populations of diploids but their impact on fitness was tested both for the diploid clones and for haploid clones derived from them. Dozens of harmful and...

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