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Article

Unpredictable fitness transitions between haploid and diploid strains of the genetically loaded yeast Saccharomyces cerevisiae.

Genetics - 1 Jan 1999

Korona R

Abstract excerpt

Mutator strains of yeast were used to accumulate random point mutations. Most of the observed changes in fitness were negative and relatively small, although major decreases and increases were also present. The average fitness of haploid strains was lowered by approximately 25% due to the accumulated genetic load. The impact of the load remained basically unchanged when a homozygous diploid was compared with the...

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Identifiers

PMID: 9872949
DOI: 10.1093/genetics/151.1.77
PMCID: PMC1460445

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Source receipt: pubmed, retrieved 7 Sept 2026.

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