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Accelerating Mutational Load Is Not Due to Synergistic Epistasis or Mutator Alleles in Mutation Accumulation Lines of Yeast.

Genetics - 1 Feb 2016

Jasmin Jean-Nicolas, Lenormand Thomas

Abstract excerpt

Much of our knowledge about the fitness effects of new mutations has been gained from mutation accumulation (MA) experiments. Yet the fitness effect of single mutations is rarely measured in MA experiments. This raises several issues, notably for inferring epistasis for fitness. The acceleration of fitness decline in MA lines has been taken as evidence for synergistic epistasis, but establishing the role of...

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PMID: 26596348
DOI: 10.1534/genetics.115.182774
PMCID: PMC4788247

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