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Article

Spontaneous mutations in diploid Saccharomyces cerevisiae: another thousand cell generations.

Genetics research - 1 Jun 2008

Hall David W, Mahmoudizad Rod, Hurd Andrew W, Joseph Sarah B

Abstract excerpt

Previously we performed a 1012-generation mutation accumulation (MA) study in yeast and found that a surprisingly large proportion of fitness-altering mutations were beneficial. To verify this result and assess the impact of sampling error in our previous study, we have continued the MA experiment for an additional 1050 cell generations and re-estimated mutation parameters. After correcting for biases due to...

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PMID: 18593510
DOI: 10.1017/S0016672308009324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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