Masking and purging mutations following EMS treatment in haploid, diploid and tetraploid yeast (Saccharomyces cerevisiae).

doi:10.1017/s0016672300004821

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Article

Masking and purging mutations following EMS treatment in haploid, diploid and tetraploid yeast (Saccharomyces cerevisiae).

Genetical research - 1 Feb 2001

Mable B K, Otto S P

Abstract excerpt

The yeast, Saccharomyces cerevisiae, was used as a model to investigate theories of ploidy evolution. Mutagenesis experiments using the alkylating agent EMS (ethane methyl sulphonate) were conducted to assess the relative importance that masking of deleterious mutations has on response to and recovery from DNA damage. In particular, we tested whether cells with higher ploidy levels have relatively higher...

Topics

Cell Division
Cell Separation
Chromosome Deletion
DNA
DNA Damage
Dose-Response Relationship, Drug
Ethyl Methanesulfonate
Evolution, Molecular
Flow Cytometry
Gene Deletion
Genes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Mating Type, Fungal

Genotype

Mating Factor

Models, Statistical

Models, Theoretical

Mutagenesis

Mutagens

Source

Open in PubMed

Identifiers

PMID: 11279834
DOI: 10.1017/s0016672300004821

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