Article
Mutational meltdown in laboratory yeast populations.
Evolution; international journal of organic evolution - 1 May 2001
Zeyl C, Mizesko M, de Visser J A
Abstract excerpt
In small or repeatedly bottlenecked populations, mutations are expected to accumulate by genetic drift, causing fitness declines. In mutational meltdown models, such fitness declines further reduce population size, thus accelerating additional mutation accumulation and leading to extinction. Because the rate of mutation accumulation is determined partly by the mutation rate, the risk and rate of meltdown are...
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