Article
The evolution of low mutation rates in experimental mutator populations of Saccharomyces cerevisiae.
Current biology : CB - 10 Jul 2012
McDonald Michael J, Hsieh Yu-Ying, Yu Yen-Hsin, Chang Shang-Lin, Leu Jun-Yi
Abstract excerpt
Mutation is the source of both beneficial adaptive variation and deleterious genetic load, fueling the opposing selective forces than shape mutation rate evolution. This dichotomy is well illustrated by the evolution of the mutator phenotype, a genome-wide 10- to 100-fold increase in mutation rat...
Topics
- Benzoquinones
- Cinnamates
- Diploidy
- Drug Resistance, Fungal
- Evolution, Molecular
- HSP90 Heat-Shock Proteins
- Hygromycin B
- Lactams, Macrocyclic
- Mutation Rate
- Phenotype
- S Phase
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Selection, Genetic